Researchers drew blood before the start of the protocols, every day for the first four days, then at day seven, day 14, and every two weeks after that. Doses ranged from 2,000 IU for daily protocols to 50,000 IU for four-weekly protocols. The researchers split the participants into a number of different supplementation protocols, providing them vitamin D2 daily, vitamin D3 daily, a daily D2/D3 combination, D2 or D3 fortnightly, D2 or D3 every four weeks, or a daily placebo, for 140 days, all in the form of standardized oral capsules.Īll participants except those in the placebo group received a total vitamin D dose of 250,000 IU over the 140 day study period, not counting any missed doses. The randomised controlled trial, by researchers in Riyadh, Saudi Arabia, enlisted 269 subjects between 18 and 60, 41% males and 59% females, who were not taking vitamin D supplements, consuming more than one serving of milk per day, or getting more than 10 hours per week of exposure to the sun. The gut-brain axis: Psychobiotic opportunity in 25 countries.Uncovering white spaces – Probiotics for a smooth menopause transition.Uncovering White Spaces – Probiotics for Pets.
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